Advances in nanotherapeutic strategies for Huntington's disease: Design, delivery, and neuroprotective mechanisms

Sameera Khan, Nargis Bano, Shakir Ahamad, N. J. Dar, Aamir Nazir, S. Bhat

Coordination chemistry reviews

Editorial: Cellular and molecular mechanisms in metabolic disorders: role of inflammation and oxidative stress

Munkhtuya Tumurkhuu, S. Bhat, Md Zakir Hossain, Mohammad Shafiq, Md. Saquib Hasnain, A. Nayak, Syed Anees Ahmed

Frontiers in Pharmacology, 2025

Editorial: Oxytosis/ferroptosis: unraveling the mechanisms and its multifaceted role in neurodegenerative diseases

N. J. Dar, David Soriano Castell, S. Bhat, Pamela Maher

Frontiers in Molecular Neuroscience, 2025

Microglial Autophagic Dysregulation in Traumatic Brain Injury: Molecular Insights and Therapeutic Avenues.

Nargis Bano, Sameera Khan, Shakir Ahamad, N. J. Dar, Hamad H. Alanazi, Aamir Nazir, S. Bhat

ACS Chemical Neuroscience, 2025

Microglial NOX2 as a therapeutic target in traumatic brain injury: Mechanisms, consequences, and potential for neuroprotection

Nargis Bano, Sameera Khan, Shakir Ahamad, N. J. Dar, Hamad H. Alanazi, Aamir Nazir, S. Bhat

Ageing Research Reviews, 2025

Small Molecules in Neurodegeneration

N. J. Dar, S. Bhat

2025

Targeting Wnt signaling pathway with small-molecule therapeutics for treating osteoporosis.

Shakir Ahamad, Mohammad Saquib, Mohd Kamil Hussain, S. Bhat

Bioorganic chemistry (Print), 2025

The Huntington's disease drug pipeline: a review of small molecules and their therapeutic targets.

Sameera Khan, Nargis Bano, V. Uversky, Shakir Ahamad, S. Bhat

Progress in Molecular Biology and Translational Science, 2025

Editorial: Proteins and protein-complexes underlying mitochondrial structure-function and metabolism: implications in diseases

M. Sabbir, N. J. Dar, S. Bhat, Hamad H. Alanazi, Jeff Perry

Frontiers in Cell and Developmental Biology, 2024

Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms

Sameera Khan, Nargis Bano, Shakir Ahamad, Urmilla John, N. J. Dar, S. Bhat

Aging and Disease, 2024

Microglia and gut microbiota: A double-edged sword in Alzheimer's disease

Nargis Bano, Sameera Khan, Shakir Ahamad, J. S. Kanshana, N. J. Dar, Sumbul Khan, Aamir Nazir, S. Bhat

Ageing Research Reviews, 2024

Neuroglia in Neurodegeneration: Exploring Glial Dynamics in Brain Disorders

N. J. Dar, Javeed Ahmad Bhat, Urmilla John, S. Bhat

Neuroglia, 2024

Unraveling the Puzzle of Therapeutic Peptides: A Promising Frontier in Huntington's Disease Treatment.

Shakir Ahamad, Nargis Bano, Sameera Khan, M. K. Hussain, S. Bhat

Journal of Medicinal Chemistry, 2024

Correction to "Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment".

Shakir Ahamad, S. Bhat

Journal of Medicinal Chemistry, 2023

Editorial: Investigating the molecular targets and therapeutic potential of Withania somnifera (Ashwagandha) in various pathophysiological conditions

N. J. Dar, S. Bhat, M. Rehman, A. Booker

Frontiers in Pharmacology, 2023

Mechanistic insights into the therapeutic potential of Angiotensin type 2 receptors (AT2R) in shaping behavior of astrocytes and microglia during hypertensive state

S. Bhat

Alzheimer's & Dementia, 2023

Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4).

N. J. Dar, Urmilla John, Nargis Bano, Sameera Khan, S. Bhat

Molecular Neurobiology, 2023

The Emerging Landscape of Natural Small-molecule Therapeutics for Huntington’s Disease

S. Bhat, Shakir Ahamad, N. J. Dar, Y. Siddique, A. Nazir

Current Neuropharmacology, 2023

Proteinopathies: Deciphering Physiology and Mechanisms to Develop Effective Therapies for Neurodegenerative Diseases

Gouri Chopra, Shabnam Shabir, Sumaira Yousuf, Simran Kauts, S. Bhat, A. H. Mir, Mahendra P. Singh

Molecular Neurobiology, 2022

Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment.

Shakir Ahamad, S. Bhat

Journal of Medicinal Chemistry, 2022

Structure‐elucidation of a bimetallic μ–hydroxo bridged Cu (II)‐flufenamate‐bpy complex and cytotoxic evaluation against MDA–MB–231 and A549 carcinoma cell lines

Imtiyaz Yousuf, I. Mantoo, M. Bashir, S. Bhat

Applied organometallic chemistry, 2022

The Emerging Landscape of Small-Molecule Therapeutics for the Treatment of Huntington's Disease.

Shakir Ahamad, S. Bhat

Journal of Medicinal Chemistry, 2022

The Protective Effects of AT2R Agonist, CGP42112A, Against Angiotensin II-Induced Oxidative Stress and Inflammatory Response in Astrocytes: Role of AT2R/PP2A/NFκB/ROS Signaling

S. Bhat, Zoya Fatima, Anika Sood, R. Shukla, K. Hanif

Neurotoxicity research, 2021

Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

S. Bhat, R. Henry, Alexa C. Blanchard, B. Stoica, David J. Loane, A. Faden

Journal of Neurochemistry, 2020

Neutral Sphingomyelinase Inhibition Alleviates LPS-Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury

Asit Kumar, R. Henry, B. Stoica, David J. Loane, Gelareh Abulwerdi, S. Bhat, A. Faden

Journal of Pharmacology and Experimental Therapeutics, 2019

Angiotensin II Receptor Blockers Attenuate Lipopolysaccharide-Induced Memory Impairment by Modulation of NF-κB-Mediated BDNF/CREB Expression and Apoptosis in Spontaneously Hypertensive Rats

Ruby Goel, S. Bhat, K. Hanif, C. Nath, R. Shukla

Molecular Neurobiology, 2018

AT2R Activation Prevents Microglia Pro-inflammatory Activation in a NOX-Dependent Manner: Inhibition of PKC Activation and p47phox Phosphorylation by PP2A

S. Bhat, Anika Sood, R. Shukla, K. Hanif

Molecular Neurobiology, 2018

Angiotensin Receptor Blockade by Inhibiting Glial Activation Promotes Hippocampal Neurogenesis Via Activation of Wnt/β-Catenin Signaling in Hypertension

S. Bhat, Ruby Goel, S. Shukla, R. Shukla, K. Hanif

Molecular Neurobiology, 2017

Platelet CD40L induces activation of astrocytes and microglia in hypertension

S. Bhat, Ruby Goel, R. Shukla, K. Hanif

Brain, behavior, and immunity, 2017

Perindopril Attenuates Lipopolysaccharide-Induced Amyloidogenesis and Memory Impairment by Suppression of Oxidative Stress and RAGE Activation.

Ruby Goel, S. Bhat, K. Hanif, C. Nath, R. Shukla

ACS Chemical Neuroscience, 2016

Angiotensin Receptor Blockade Modulates NFκB and STAT3 Signaling and Inhibits Glial Activation and Neuroinflammation Better than Angiotensin-Converting Enzyme Inhibition

S. Bhat, Ruby Goel, R. Shukla, K. Hanif

Molecular Neurobiology, 2015

Hypertension exacerbates predisposition to neurodegeneration and memory impairment in the presence of a neuroinflammatory stimulus: Protection by angiotensin converting enzyme inhibition

Ruby Goel, S. Bhat, N. Rajasekar, K. Hanif, C. Nath, R. Shukla

Pharmacology, Biochemistry and Behavior, 2015